Avisynth+ MT is more commonly used now, and there aren't very many reports of issues like yours
It could be any number of things . It could be your hardware, or one of your plugins, or a specific issue with that x264 build.
If I had to guess, one of those plugins have threading issues. Check your plugins, for example
Quote:
LoadPlugin("C:\Program Files (x86)\AviSynth+\plugins+\mt_masktools-26.dll")
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That's not the pinterf branch of masktools2. That's the old masktool2. Many of the newer plugins have auto register for MT modes
So go through each of your plugins used in that script and make sure they are correct and updated
If you still have problems, use a methodical process of elimination
eg. start with using the script with different encoder like xvid in vdub, or just avsmeter . If that works, then problem is either with that x264 build or megui
If it's the same crash then start removing filters one by one and repeat