FSE does not really have much benefits on Windows 10. Functionality that required FSE on older versions of Windows also works in windowed mode in current Windows 10.
If you really need FSE, then disable "fullscreen optimizations" in the compatibility settings of your player (right-click on .exe > properties > compatibility). Also disable the game bar in Windows 10.
I think I read somewhere on nvidia forum that the vsync issue might get fixed in next Windows 10 build.
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