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Nvidia drivers will vary per release. Some do have issues with custom resolutions and HDR switching, but others don't. 12-bit custom resolutions simply do not work with madVR, but may work with the Custom Resolution Utility (CRU).
I don't know of anyone who uses the RX Vega 56 with madVR. You should try both and report back on the performance of the Vega 56.
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