Hello, and welcome to the forums.
The best AviSynth upscaler is
Nnedi3_rpow2. An example for a script might go:
nnedi3_rpow2(rfactor=2,cshift="Spline16resize",fwidth=1920,fheight=1080)
I usually follow upscaling with some sharpening. Others might do it differently.
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Deinterlace is an option, but I really don't know the best deinterlacer for old anime.
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Most likely it shouldn't be deinterlaced but IVTC'd. Please provide a 10 second sample from the source DVD so we can have a look and confirm.
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...the best way to convert the video without losing color or frames.
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When upscaling DVD to hi-def, you should also convert the colorimetry to Rec.709 from the source Rec.601.