I would use L-SMASH Works (LSMASHSource.dll) as AviSynth native plugin and use LSMASHVideoSource() because MOV is an ISO Media container, and the L-SMASH splitter can use the keyframe index chunk inside the MOV file.
I see no reason why anyone would try to use a VirtualDub2 input plugin in AviSynth, I am not even sure if that is possible at all (LoadVirtualDubPlugin loads video filter plugins = *.vdf, not input plugins).
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