Watching 1080p at 1440p is actually harder than watching 1080p at 4K. For 4K you simply double it (with NGU) but with 1440p you have to downscale it afterwards. I do not think there is anything to improve for watching at 1440p.
My presets are intended to be general but I do want Anime to look good as part of that. I might chose different settings if I didn't need Anime to look good as well but it would not be very different (i.e. changing NGU AA to NGU Sharp).
