Yes, as the memory usage (cache) is somewhat linear to the number of Prefetch threads, you are probably experiencing memory full issues. You can try AvsMeter with your script to see whether the memory usage is the bottleneck.
As DJATOM said you can experiment with SetMemoryMax and Prefetch count to see where it saturates your available memory. x64 version is recommended however (I don't know which version you are using)
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