shekh,
Drag any YUV video onto VirtualDub2, add a levels filter (input 0-64, output 0-255) and it comes out all messed up:
https://i.imgur.com/YXOrHaT.png
It seems to be skipping every fourth pixel, or possibly repeating pixels.
The problem goes away if I untick "Operate in luma instead of RGB", or if the input is RGB itself.