Which queue in madVR drops first?
Do you have any Flush & Wait settings enabled? If so, try setting all to "Don't Flush".
What CPU, GPU, OS?
I'm not seeing anything particularly abnormal as far as CPU usage on the second sample on my System.
704x480->853x480 = 1% CPU Usage by XySubFilter
704x480->2560x1440 = 3% CPU Usage by XySubFilter
The first sample likely just caches well by chance.
Just to make sure, I'll have our dev double check that nothing strange is going on with second sample.
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